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NOX2-IN-2 (diTFA)

NOX2-IN-2 diTFA (compound 33) is a potent NOX2 inhibitor targeting the p47phox-p22phox protein-protein interaction with a Ki of 0.24 μM. NOX2-IN-2 diTFA inhibits ROS production derived from NOX2 in cells[1].

Product Specifications

CAS Number

[2648709-80-0]

UNSPSC

12352005

Target

NADPH Oxidase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/nox2-in-2-ditfa.html

Purity

98.15

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

NC1=NC2=CC=C(C=C2C=C1)OCC3=CN(N=N3)CCOCCOC4=CC=C5N=C(C=CC5=C4)N.OC(C(F)(F)F)=O.OC(C(F)(F)F)=O

Molecular Formula

C29H27F6N7O7

Molecular Weight

699.56

References & Citations

[1]Jie Zang, et al.Targeting NOX2 with Bivalent Small-Molecule p47phox-p22phox Inhibitors. J Med Chem. 2023 Oct 19.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Curated Selection

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