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Mindeudesivir

Product Specifications

UNSPSC Description

GS-621763-d1 is the deuterium labeled GS-621763 (HY-145119)[1]. GS-621763, an orally bioavailable proagent of GS-441524, shows antiviral activity against SARS-CoV-2 pathogenesis in mice[2].

Target Antigen

Isotope-Labeled Compounds

Type

Isotope-Labeled Compounds

Related Pathways

Others

Field of Research

Others

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

N#C[C@](O[C@@H]1COC(C(C)C)=O)(C2=CC([2H])=C3N2N=CN=C3N)[C@@H]([C@@H]1OC(C(C)C)=O)OC(C(C)C)=O

Molecular Weight

502.54

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.|[2]Schäfer A, et al. Therapeutic efficacy of an oral nucleoside analog of remdesivir against SARS-CoV-2 pathogenesis in mice. bioRxiv [Preprint]. 2021 Sep 17:2021.09.13.460111.

Shipping Conditions

Room Temperature

Clinical Information

Phase 1

CAS Number

2647442-33-7

Available Sizes

Curated Selection

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