Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

Phrixotoxin 3-NH2 (TFA)

Phrixotoxin 3-NH2 TFA is a derivative of Phrixotoxin 3 TFA. Phrixotoxin 3 TFA is a potent blocker of voltage-gated sodium channels, with IC50s of 0.6, 42, 72, 288, 610 nM for NaV1.2, NaV1.3, NaV1.4, NaV1.1 and NaV1.5, respectively. Phrixotoxin 3 TFA modulates voltage-gated sodium channels with properties similar to those of typical gating-modifier toxins, both by causing a depolarizing shift in gating kinetics and by blocking the inward component of the sodium current[1].

Product Specifications

UNSPSC

12352209

Target

Sodium Channel

Type

Peptides

Related Pathways

Membrane Transporter/Ion Channel

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/phrixotoxin-3-nh2-tfa.html

Purity

98.63

Solubility

DMSO : ≥ 100 mg/mL

Smiles

O=C(N[C@@H](CSSC[C@@H](C(N[C@@H](CCCNC(N)=N)C(N1[C@@H](CCC1)C(N[C@@H](CC(N)=O)C(N[C@@H](CC(C)C)C(N[C@H]2C(C)C)=O)=O)=O)=O)=O)NC3=O)C(N[C@@H](CC(C)C)C(NCC(N[C@@H](CC4=CC=CC=C4)C(N[C@@H](CC(C)C)C(N[C@@H](CC5=CNC6=CC=CC=C56)C(N[C@@H](CCCCN)C(N[C@@H](CSSC[C@@H](C(N[C@@H](CO)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCCN)C(N[C@@H](CC(O)=O)C(N[C@@H](CCCCN)C(N[C@H]7CC8=CNC9=CC=CC=C89)=O)=O)=O)=O)=O)=O)NC2=O)C(N[C@@H](CC(N)=O)C(N%10[C@@H](CCC%10)C(N[C@@H](CO)C(N[C@@H](CC(N)=O)C(N[C@@H](CC(O)=O)C(N[C@@H](CCCCN)C(N[C@H]3CSSC[C@@H](C(N[C@@H](CCCCN)C(N[C@@H](CC%11=CC=C(C=C%11)O)C(N[C@@H](CCC(N)=O)C(N[C@@H]([C@@H](C)CC)C(N)=O)=O)=O)=O)=O)NC7=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CC(O)=O)N.OC(C(F)(F)F)=O.[x]

Molecular Formula

C176H270N52O47S6.xC2HF3O2

Molecular Weight

4058.74 (free base)

References & Citations

[1]Bosmans F, et, al. Four novel tarantula toxins as selective modulators of voltage-gated sodium channel subtypes. Comparative Study Mol Pharmacol. 2006 Feb; 69 (2) : 419-29.

Shipping Conditions

Blue Ice

Storage Conditions

-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)

Scientific Category

Peptides

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

More Discoveries

Explore Other Products

Browse additional items from our catalog

C-C motif chemokine 2
AP81308 1 mg

C-C motif chemokine 2

Sign In for Pricing
View Details
RNU7-41P sgRNA CRISPR Lentivector set (Human)
K1858601 3x 1.0 µg

RNU7-41P sgRNA CRISPR Lentivector set (Human)

Sign In for Pricing
View Details
0610010K14Rik Protein Vector (Mouse) (pPM-C-His)
PV146157 500 ng

0610010K14Rik Protein Vector (Mouse) (pPM-C-His)

Sign In for Pricing
View Details
MER Antibody
OAAD00251-100UL 0.1 mL

MER Antibody

Sign In for Pricing
View Details
Recombinant Human HBS1L Protein, N-His
bs-104363P-01 20 µg

Recombinant Human HBS1L Protein, N-His

Sign In for Pricing
View Details
Recombinant Human HBS1L Protein, N-His
bs-104363P-02 50 µg

Recombinant Human HBS1L Protein, N-His

Sign In for Pricing
View Details