PKI (14-24) amide (TFA)

PKI (14-24) amide TFA is a potent PKA inhibitor. PKI (14-24) amide strongly inhibited cyclic AMP-dependent protein kinase activity in the cell homogenate[1][2].

Product Specifications

CAS Number

[1293946-39-0]

UNSPSC

12352209

Target

PKA

Type

Peptides

Related Pathways

Stem Cell/Wnt; TGF-beta/Smad

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/pki-14-24-amide-tfa.html

Purity

98.27

Solubility

H2O : 100 mg/mL (ultrasonic)

Smiles

N=C(N)NCCC[C@H](NC(CN)=O)C(N[C@@H]([C@H](O)C)C(NCC(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC(N)=O)C(N[C@@H](C)C(N[C@@H]([C@@H](C)CC)C(N[C@H](C(N[C@H](C(N)=O)CC(O)=O)=O)CC1=CN=CN1)=O)=O)=O)=O)=O)=O)=O)=O.OC(C(F)(F)F)=O.[x]

Molecular Formula

C49H86N24O15.xC2HF3O2

Molecular Weight

1251.36 (free base)

References & Citations

[1]Nörenberg W, et al. Adenosine A2A receptors inhibit the conductance of NMDA receptor channels in rat neostriatal neurons. Amino Acids. 1998;14 (1-3) :33-9. |[2]Takuma T. Evidence against direct involvement of cyclic AMP-dependent protein phosphorylation in the exocytosis of amylase. Biochem J. 1988 Dec 15;256 (3) :867-71.