BAR501
BAR501 is a potent and selective agonist of GPBAR1 with an EC50 of 1 μM.
Product Specifications
CAS Number
[1632118-69-4]
UNSPSC
12352211
Target
G protein-coupled Bile Acid Receptor 1
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
COVID-19-immunoregulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/BAR501.html
Purity
99.90
Solubility
DMSO : ≥ 50 mg/mL|Ethanol : 120 mg/mL (ultrasonic)
Smiles
C[C@H](CCCO)[C@@]1([H])CC[C@@]2([H])[C@]3([H])[C@@H](O)[C@@H](CC)[C@]4([H])C[C@H](O)CC[C@]4(C)[C@@]3([H])CC[C@@]21C
Molecular Formula
C26H46O3
Molecular Weight
406.64
References & Citations
[1]Renga B, et al. Reversal of Endothelial Dysfunction by GPBAR1 Agonism in Portal Hypertension Involves a AKT/FOXOA1 Dependent Regulation of H2S Generation and Endothelin-1. PLoS One. 2015 Nov 5;10 (11) :e0141082.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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