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BAR501

BAR501 is a potent and selective agonist of GPBAR1 with an EC50 of 1 μM.

Product Specifications

CAS Number

1632118-69-4

UNSPSC

12352211

Target

G protein-coupled Bile Acid Receptor 1

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

COVID-19-immunoregulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/BAR501.html

Purity

99.90

Solubility

DMSO : ≥ 50 mg/mL|Ethanol : 120 mg/mL (ultrasonic)

Smiles

C[C@H](CCCO)[C@@]1([H])CC[C@@]2([H])[C@]3([H])[C@@H](O)[C@@H](CC)[C@]4([H])C[C@H](O)CC[C@]4(C)[C@@]3([H])CC[C@@]21C

Molecular Formula

C26H46O3

Molecular Weight

406.64

References & Citations

[1]Renga B, et al. Reversal of Endothelial Dysfunction by GPBAR1 Agonism in Portal Hypertension Involves a AKT/FOXOA1 Dependent Regulation of H2S Generation and Endothelin-1. PLoS One. 2015 Nov 5;10 (11) :e0141082.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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