Hi 76-0079

Hi 76-0079 (NNC0076-0079; 76-0079) is a lipase inhibitor that specifically targets hormone-sensitive lipase (HSL) . Hi 76-0079 inhibits PNPB Hydrolysis in cell lysates of HEK293A cells overexpressing Lipe with an IC50 value of 0.1 μM. Hi 76-0079 synergizes with the ATGL inhibitor Atglistatin (HY-15859) to block lipolysis in vitro. Hi 76-0079 can be used for the study of lipid metabolism[1][2].

Product Specifications

CAS Number

[374567-94-9]

Product Name Alternative

NNC0076-0079; 76-0079

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

Lipase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/hi-76-0079.html

Purity

99.90

Solubility

DMSO : 200 mg/mL (ultrasonic)

Smiles

O=C(NN1CCOCC1)OC2=CC=C(C=C2)Cl

Molecular Formula

C11H13ClN2O3

Molecular Weight

256.69

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Mayer N, et al. Development of small-molecule inhibitors targeting adipose triglyceride lipase. Nat Chem Biol. 2013 Dec;9 (12) :785-7.|[2]Sakai K, et al. Critical role of neutral cholesteryl ester hydrolase 1 in cholesteryl ester hydrolysis in murine macrophages. J Lipid Res. 2014 Oct;55 (10) :2033-40.