Hsp90-Cdc37-IN-3

Hsp90-Cdc37-IN-3 (Compound 9) is a novel celastrol imidazole derivative with anticancer activity. Hsp90-Cdc37-IN-3 inhibits Hsp90 Cdc37 by covalent-binding, and induces apoptosis[1].

Product Specifications

CAS Number

[2361009-68-7]

UNSPSC

12352005

Target

Apoptosis; HSP

Type

Reference compound

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/hsp90-cdc37-in-3.html

Purity

98.09

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C1C(O)=C(C2=CC=C3[C@](C)([C@]4(CC[C@]3(C2=C1)C)C)CC[C@@]5([C@@]4([H])C[C@](C(OCCCN6C(Cl)=NC([N+]([O-])=O)=C6)=O)(CC5)C)C)C

Molecular Formula

C35H44ClN3O6

Molecular Weight

638.19

References & Citations

[1]Na Li, et al. Discovery of Novel Celastrol-Imidazole Derivatives with Anticancer Activity In Vitro and In Vivo. J Med Chem. 2022 Mar 24;65 (6) :4578-4589.