Hsp90-Cdc37-IN-3
Hsp90-Cdc37-IN-3 (Compound 9) is a novel celastrol imidazole derivative with anticancer activity. Hsp90-Cdc37-IN-3 inhibits Hsp90 Cdc37 by covalent-binding, and induces apoptosis[1].
Product Specifications
CAS Number
2361009-68-7
UNSPSC
12352005
Target
Apoptosis; HSP
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/hsp90-cdc37-in-3.html
Purity
98.09
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C1C(O)=C(C2=CC=C3[C@](C)([C@]4(CC[C@]3(C2=C1)C)C)CC[C@@]5([C@@]4([H])C[C@](C(OCCCN6C(Cl)=NC([N+]([O-])=O)=C6)=O)(CC5)C)C)C
Molecular Formula
C35H44ClN3O6
Molecular Weight
638.19
References & Citations
[1]Na Li, et al. Discovery of Novel Celastrol-Imidazole Derivatives with Anticancer Activity In Vitro and In Vivo. J Med Chem. 2022 Mar 24;65 (6) :4578-4589.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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