Dipentyl phthalate
Dipentyl phthalate is an endocrine-disrupting phthalate plasticizer. Dipentyl phthalate increases AMPK phosphorylation and decreases AKT1 phosphorylation and SIRT1 levels. Dipentyl phthalate reduces adrenocorticotropic hormone levels. Dipentyl phthalate is a testicular toxicant[1].
Product Specifications
CAS Number
131-18-0
UNSPSC
12352005
Hazard Statement
H360, H400
Target
Akt; AMPK
Type
Reference compound
Related Pathways
Epigenetics; PI3K/Akt/mTOR
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/dipentyl-phthalate.html
Purity
99.51
Solubility
DMSO : ≥ 100 mg/mL
Smiles
O=C(OCCCCC)C1=CC=CC=C1C(OCCCCC)=O
Molecular Formula
C18H26O4
Molecular Weight
306.40
Precautions
H360, H400
References & Citations
[1]Haiqiong Chen, et al. Exposure to dipentyl phthalate in utero disrupts the adrenal cortex function of adult male rats by inhibiting SIRT1/PGC-1α and inducing AMPK phosphorylation. Environ Toxicol. 2023 May;38 (5) :997-1010.|[2]Bethany R Hannas, et al. Dipentyl phthalate dosing during sexual differentiation disrupts fetal testis function and postnatal development of the male Sprague-Dawley rat with greater relative potency than other phthalates. Toxicol Sci. 2011 Mar;120 (1) :184-93.
Shipping Conditions
Room Temperature
Storage Conditions
Store at room temperature 3 years
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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