Mirzotamab

Mirzotamab is an IgG1κ monoclonal antibody targeting to CD276/B7-H3 with anti-tumor activity. Mirzotamab conjugates with Clezutoclax (HY-137774), a BCL inhibitor to form Mirzotamab clezutoclax (HY-P99741), involving in research with taxane research in relapsed/refractory solid tumors. Mirzotamab clezutoclax (ABBV-155) is a targeted antibody drug conjugate (ADC) [1][2][3].

Product Specifications

CAS Number

[2229859-11-2]

UNSPSC

12352203

Target

ADC Antibody; CD276/B7-H3

Type

Inhibitory Antibodies

Related Pathways

Antibody-drug Conjugate/ADC Related; Immunology/Inflammation

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/mirzotamab.html

Purity

99.45

Solubility

10 mM in DMSO

Smiles

[Mirzotamab]

Molecular Weight

(144.86 kDa)

References & Citations

[1]Tolcher A W, et al. A first-in-human study of mirzotamab clezutoclax as monotherapy and in combination with taxane therapy in relapsed/refractory solid tumors: Dose escalation results. 2021. |[2]Cai Jiaqiang, et al. Antibody-drug conjugate containing BCL-2 family proteolysis agent, preparation method therefor, and use thereof. WO2024153185. 2024.07.25.|[3]Nathanson, David A., et al. Combination therapy for treating glioblastoma. WO2022231996. 2022.11.03.