Creatine

Creatine, an endogenous amino acid derivative, plays an important role in cellular energy, especially in muscle and brain.

Product Specifications

CAS Number

[57-00-1]

UNSPSC

12352211

Hazard Statement

H302, H315, H319, H335

Target

Dopamine Receptor; Endogenous Metabolite

Type

Natural Products

Related Pathways

GPCR/G Protein; Metabolic Enzyme/Protease; Neuronal Signaling

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Cancer; Metabolic Disease; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/2-_1-Methylguanidino_acetic_acid.html

Concentration

10mM

Purity

99.95

Solubility

H2O : 6.25 mg/mL (ultrasonic)

Smiles

CN(C(N)=N)CC(O)=O

Molecular Formula

C4H9N3O2

Molecular Weight

131.13

Precautions

H302, H315, H319, H335

References & Citations

[1]Nouioua S, et al. Creatine deficiency syndrome. A treatable myopathy due to arginine-glycine amidinotransferase (AGAT) deficiency. Neuromuscul Disord. 2013 Aug;23 (8) :670-4.|[2]Gerber I, et al., Stimulatory effects of creatine on metabolic activity, differentiation and mineralization of primary osteoblast-like cells in monolayer and micromass cell cultures. Eur Cell Mater. 2005 Jul 15;10:8-22. |[3]Guidi C, et al., Differential effect of creatine on oxidatively-injured mitochondrial and nuclear DNA. Biochim Biophys Acta. 2008 Jan;1780 (1) :16-26. |[4]Cunha MP, et al., Antidepressant-like effect of creatine in mice involves dopaminergic activation. J Psychopharmacol. 2012 Nov;26 (11) :1489-501.