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[Lys5,MeLeu9,Nle10]Neurokinin A(4-10)

Product Specifications

UNSPSC Description

[Lys5,MeLeu9,Nle10]Neurokinin A(4-10) (LMN-NKA), an analogue of Neurokinin A, is a selective and potent NK2R agonist. [Lys5,MeLeu9,Nle10]Neurokinin A(4-10) has prokinetic activity. [Lys5,MeLeu9,Nle10]Neurokinin A(4-10) can be used to study the roles of the NK-2 receptor in smooth muscle contraction in numerous tissues[1][2][3].

Target Antigen

Neurokinin Receptor

Type

Peptides

Related Pathways

GPCR/G Protein;Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/lys5-meleu9-nle10-neurokinin-a-4-10.html

Purity

99.83

Solubility

DMSO : 25 mg/mL (ultrasonic)

Smiles

OC(C[C@H](N)C(N[C@@H](CCCCN)C(N[C@H](C(N[C@@H](C(C)C)C(NCC(N(C)[C@@H](CC(C)C)C(N[C@H](C(O)=O)CCCC)=O)=O)=O)=O)CC1=CC=CC=C1)=O)=O)=O

Molecular Weight

804.97

References & Citations

[1]Rupniak NMJ, et al. Prokinetic effects of the neurokinin NK2 receptor agonist [Lys5,MeLeu9,Nle10]-NKA(4-10) on bladder and colorectal activity in minipigs. Neuropeptides. 2019 Oct;77:101956. |[2]Rupniak NMJ, et al. [Lys5,MeLeu9,Nle10]-NKA(4-10) Elicits NK2 Receptor-Mediated Micturition and Defecation, and NK1 Receptor-Mediated Emesis and Hypotension, in Conscious Dogs. J Pharmacol Exp Ther. 2018 Jul;366(1):136-144. |[3]Sara Good, et al. [Lys5, MeLeu9, Nle10]NKA-4-10. Reference Module in Biomedical Sciences. 2019.

Shipping Conditions

Blue Ice

Storage Conditions

-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)

Product Datasheet

http://file.medchemexpress.com/batch_PDF/HY-P3849/Lys5-MeLeu9-Nle10-Neurokinin-A-4-10-DataSheet-MedChemExpress.pdf

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-P3849/Lys5-MeLeu9-Nle10-Neurokinin-A-4-10-SDS-MedChemExpress.pdf

Clinical Information

No Development Reported

CAS Number

149270-28-0

Available Sizes

Curated Selection

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