RIP1 kinase inhibitor 9
RIP1 kinase inhibitor 9 (compound SY-1) is a selective RIP kinase inhibitor. RIP1 kinase inhibitor 9 effectively suppresses the central inflammatory response induced by epilepsy. RIP1 kinase inhibitor 9 inhibits Z-VAD-FMK -induced necroptosis in HT-29 cells with an EC50 of 7.04 nM[1].
Product Specifications
UNSPSC
12352005
Target
Necroptosis; RIP kinase
Type
Reference compound
Related Pathways
Apoptosis
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/rip1-kinase-inhibitor-9.html
Solubility
10 mM in DMSO
Smiles
CN1C([C@H](COC2=CC=CC=C21)NC(C3=CC4=C(NC=C4C5=CC=CC=C5)C=C3)=O)=O
Molecular Formula
C25H21N3O3
Molecular Weight
411.45
References & Citations
[1]Jiang R, et al. Scaffold hopping derived novel benzoxazepinone receptor-interacting protein kinase 1 (RIP1) inhibitors as anti-necroptosis agents: Anti-inflammatory effect in systemic inflammatory response syndrome (SIRS) and epilepsy. Eur J Med Chem. 2024 Mar 9;269:116304.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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