A457
A457 is a prokineticin receptor PKR2 antagonist, with an IC50 of 102 nM. A457 can rescue the cell surface expression and function of P290S PKR2, but not W178S and G234D PKR2[1].
Product Specifications
CAS Number
[1233923-95-9]
UNSPSC
12352005
Target
Prokineticin Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
Neuroscience-Neuromodulation
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/a457.html
Smiles
O=C(N(CC(C)C)CC1=CC(Cl)=C2OCCCOC2=C1)C3CN(CC3)CC4=CC=CC=C4
Molecular Formula
C26H33ClN2O3
Molecular Weight
457.00
References & Citations
[1]Dan-Na Chen, et al. Functional rescue of Kallmann syndrome-associated prokineticin receptor 2 (PKR2) mutants deficient in trafficking. J Biol Chem. 2014 May 30;289 (22) :15518-26.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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