NGB 2904
NGB 2904 is a potent, selective, orally active and brain-penetrated antagonist of dopamine D3 receptor, with a Ki of 1.4 nM. NGB 2904 shows selectivity for D3 over D2, 5-HT2, α1, D4, D1 and D5 receptors (Kis=217, 223, 642, >5000, >10000 and >10000 nM, respectively) . NGB 2904 antagonizes Quinpirole-stimulated mitogenesis[1][2].
Product Specifications
CAS Number
189060-98-8
UNSPSC
12352005
Target
Dopamine Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/ngb-2904.html
Purity
98.28
Solubility
Ethanol : 4.55 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(C1=CC(CC2=C3C=CC=C2)=C3C=C1)NCCCCN4CCN(C5=CC=CC(Cl)=C5Cl)CC4
Molecular Formula
C28H29Cl2N3O
Molecular Weight
494.46
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
D3 Receptor
Available Sizes
Frequently Asked Questions
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