Cilostamide
Cilostamide is a selective and potent PDE3 inhibitor, with IC50s of 27 nM and 50 nM for PDE3A and PDE3B, respectively, and has antithrombotic and anti-intimal hyperplastic activity.
Product Specifications
CAS Number
68550-75-4
Product Name Alternative
OPC3689
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Phosphodiesterase (PDE)
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/Cilostamide.html
Purity
99.13
Solubility
DMSO : 31 mg/mL (ultrasonic; warming)
Smiles
O=C(N(C1CCCCC1)C)CCCOC2=CC3=C(NC(C=C3)=O)C=C2
Molecular Formula
C20H26N2O3
Molecular Weight
342.43
Precautions
H302, H315, H319, H335
References & Citations
[1]Sudo T, et al. Potent effects of novel anti-platelet aggregatory cilostamide analogues on recombinant cyclic nucleotide phosphodiesterase isozyme activity. Biochem Pharmacol. 2000 Feb 15;59 (4) :347-56.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PDE3
Available Sizes
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