Cilostamide

Cilostamide is a selective and potent PDE3 inhibitor, with IC50s of 27 nM and 50 nM for PDE3A and PDE3B, respectively, and has antithrombotic and anti-intimal hyperplastic activity.

Product Specifications

CAS Number

68550-75-4

Product Name Alternative

OPC3689

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Phosphodiesterase (PDE)

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/Cilostamide.html

Purity

99.13

Solubility

DMSO : 31 mg/mL (ultrasonic; warming)

Smiles

O=C(N(C1CCCCC1)C)CCCOC2=CC3=C(NC(C=C3)=O)C=C2

Molecular Formula

C20H26N2O3

Molecular Weight

342.43

Precautions

H302, H315, H319, H335

References & Citations

[1]Sudo T, et al. Potent effects of novel anti-platelet aggregatory cilostamide analogues on recombinant cyclic nucleotide phosphodiesterase isozyme activity. Biochem Pharmacol. 2000 Feb 15;59 (4) :347-56.