Sodium nitroprusside
Sodium nitroprusside (Ro 21-2498) is a potent vasodilator working through releasing NO spontaneously in blood.
Product Specifications
CAS Number
14402-89-2
Product Name Alternative
Ro 21-2498
UNSPSC
12352300
Hazard Statement
H301
Target
Angiotensin Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/Nitroprusside-Sodium.html
Concentration
10mM
Purity
99.17
Solubility
DMSO : 33.33 mg/mL (ultrasonic) |H2O : 100 mg/mL (ultrasonic)
Smiles
N#C[Fe-2](C#N)(C#N)(C#N)(N=O)C#N.[Na+].[Na+]
Molecular Formula
C5FeN6Na2O
Molecular Weight
261.92
Precautions
H301
References & Citations
[1]Wink, D.A., et al., The effect of various nitric oxide-donor agents on hydrogen peroxide-mediated toxicity: a direct correlation between nitric oxide formation and protection. Arch Biochem Biophys, 1996. 331 (2) : p. 241-8.|[2]Garg, U.C. and A. Hassid, Nitric oxide-generating vasodilators and 8-bromo-cyclic guanosine monophosphate inhibit mitogenesis and proliferation of cultured rat vascular smooth muscle cells. J Clin Invest, 1989. 83 (5) : p. 1774-7.|[3]Namazi, H., Sodium nitroprusside as a nitric oxide donor in a rat intestinal ischemia reperfusion model: a novel molecular mechanism. Clinics (Sao Paulo), 2008. 63 (3) : p. 405.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
Launched
Citation 01
Appl Biochem Biotechnol. 2025 Jun;197 (6) :3964-3981.|Biochim Biophys Acta Mol Basis Dis. 2024 Jul 25:167437.|Br J Pharmacol. 2021 Dec;178 (23) :4646-4662.|J Ethnopharmacol. 2024 Aug 23:118727.|J Invest Dermatol. 2025 Sep 15:S0022-202X (25) 02428-5.|J Neuroinflammation. 2023 Feb 24;20 (1) :49.|Mol Cell Biochem. 2025 Aug 3.|Neuroscience. 2024 Dec 17:563:175-187.|Phytochem Lett. 2025 Oct 17;70:104058.|Plant J. 2025 Jul;123 (2) :e70379.|Redox Biol. 2024 Feb:69:103004.|Theriogenology. 2025 May 29:245:117517.|Turk J Med Sci. 2025 Feb 19;55 (2) :509-517. |Chem Eng J. 15 August 2022, 136169.|Exp Eye Res. 2024 Jun:243:109886.
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