Pipecolic acid-d9

Pipecolic acid-d9 is the deuterium labeled Pipecolic acid. Pipecolic acid is a metabolite of lysine and an important precursor for many useful microbial secondary metabolites. Pipecolic acid slows ferroptosis in diabetic retinopathy by inhibiting the YAP-GPX4 signaling pathway. In addition, Pipecolic acid can be used as a diagnostic marker for pyridoxine-dependent epilepsy[1][2][3].

Product Specifications

CAS Number

790612-94-1

UNSPSC

12352005

Target

Endogenous Metabolite; Ferroptosis; Glutathione Peroxidase; Isotope-Labeled Compounds; YAP

Type

Isotope-Labeled Compounds

Related Pathways

Apoptosis; Metabolic Enzyme/Protease; Others; Stem Cell/Wnt

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Infection

Purity

99.9

Solubility

H2O : 50 mg/mL (ultrasonic; warming)

Smiles

OC(C1([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])N1)=O

Molecular Formula

C6H2D9NO2

Molecular Weight

138.21

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]He M, et al. Pipecolic acid in microbes: biosynthetic routes and enzymes. J Ind Microbiol Biotechnol. 2006 Jun;33 (6) :401-7.|[3]Plecko B, et, al. Pipecolic acid as a diagnostic marker of pyridoxine-dependent epilepsy. Neuropediatrics. 2005 Jun;36 (3) :200-5.