(-) -Dizocilpine (maleate)

(-) -Dizocilpine maleate ((-) -MK-801 maleate) is a less active (-) -enantiomer of Dizocilpine. (-) -Dizocilpine maleate is a selective and non-competitive N-methyl-D-aspartate (NMDA) receptor antagonist with a Ki of 211.7 nM. (-) -Dizocilpine maleate has antidepressant effects[1][2].

Product Specifications

CAS Number

[121917-57-5]

Product Name Alternative

(-) -MK-801 (maleate)

UNSPSC

12352005

Target

IGluR

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/_-_-MK-801-Maleate.html

Purity

99.92

Solubility

DMSO : 100 mg/mL (ultrasonic) |Ethanol : 25 mg/mL (ultrasonic) |H2O : 8.33 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

C[C@@]1(N2)C3=CC=CC=C3C[C@H]2C4=CC=CC=C14.O=C(O)/C=C\C(O)=O

Molecular Formula

C20H19NO4

Molecular Weight

337.37

References & Citations

[1]Yang B, et al. Antidepressant Effects of (+) -MK-801 and (-) -MK-801 in the Social Defeat Stress Model. Int J Neuropsychopharmacol. 2016 Dec 30;19 (12) .|[2]Nishimura M, et al. MK-801 blocks monoamine transporters expressed in HEK cells. FEBS Lett. 1998 Feb 27;423 (3) :376-80.