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RN-9893

Product Specifications

UNSPSC Description

RN-9893 is a potent and selective TRPV4 receptor antagonist with IC50 values of 320, 420 and 660 nM for mouse, human and rat channels, respectively[1].

Target Antigen

TRP Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel;Neuronal Signaling

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/rn-9893.html

Purity

99.91

Solubility

DMSO : 250 mg/mL (ultrasonic)

Smiles

O=S(C(C=C1)=CC=C1NC(C2=C([N+]([O-])=O)C=C(C(F)(F)F)C=C2)=O)(N3CCN(C(C)C)CC3)=O

Molecular Weight

500.49

References & Citations

[1]Wei ZL, et, al. Identification of orally-bioavailable antagonists of the TRPV4 ion-channel. Bioorg Med Chem Lett. 2015 Sep 15;25(18):4011-5.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Product Datasheet

http://file.medchemexpress.com/batch_PDF/HY-110270/RN-9893-DataSheet-MedChemExpress.pdf

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-110270/RN-9893-SDS-MedChemExpress.pdf

Clinical Information

No Development Reported

CAS Number

1803003-68-0

Available Sizes

Curated Selection

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