5,10-Dideazafolic acid
5,10-Dideazafolic acid is a 5,10-dideaza-5,6,7,8-tetrahydrofola analogue, which exhibits some inhibitory activity against glycine amide ribonucleotide formyltransferase (GARFT) (Ki=13 μM) [1].
Product Specifications
CAS Number
85597-18-8
UNSPSC
12352005
Target
Antifolate
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/5-10-dideazafolic-acid.html
Smiles
O=C(CC[C@H](NC(C1=CC=C(C=C1)CCC2=CN=C(NC(N)=NC3=O)C3=C2)=O)C(O)=O)O
Molecular Formula
C21H21N5O6
Molecular Weight
439.42
References & Citations
[1]Baldwin, et al. "Structural features of 5, 10-dideaza-5, 6, 7, 8-tetrahydrofolate that determine inhibition of mammalian glycinamide ribonucleotide formyltransferase." Biochemistry 30.7 (1991) : 1997-2006.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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