K-Ras (G12C) inhibitor 12
K-Ras (G12C) inhibitor 12 is an irreversible inhibitor of K-Ras (G12C) . K-Ras (G12C) inhibitor 12 can alter the nucleotide-binding preference of K-Ras and block its interaction with effector proteins. K-Ras (G12C) inhibitor 12 can reduce cell viability and induce apoptosis in lung cancer cell lines with G12C mutations. K-Ras (G12C) inhibitor 12 has anti-tumor activity[1].
Product Specifications
CAS Number
[1469337-95-8]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Apoptosis; Ras
Type
Reference compound
Related Pathways
Apoptosis; GPCR/G Protein; MAPK/ERK Pathway
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/K-Ras_G12C_-inhibitor-12.html
Concentration
10mM
Purity
99.57
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
C=CC(N1CCN(C(CNC2=CC(I)=C(Cl)C=C2O)=O)CC1)=O
Molecular Formula
C15H17ClIN3O3
Molecular Weight
449.67
Precautions
H302, H315, H319, H335
References & Citations
[1]Ostrem JM, et al. K-Ras (G12C) inhibitors allosterically control GTP affinity and effector interactions. Nature. 2013 Nov 28;503 (7477) :548-551.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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