(Z) -PUGNAc
(Z) -PUGNAc is a potent O-GlcNAcase inhibitor. (Z) -PUGNAc is a vastly more potent inhibitor of O-GlcNAcase than the E form[1].
Product Specifications
CAS Number
[132489-69-1]
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
OGA
Type
Reference compound
Related Pathways
Neuronal Signaling
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/z-pugnac.html
Concentration
10mM
Purity
99.13
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=C(NC1=CC=CC=C1)O/N=C2[C@@H]([C@H]([C@@H]([C@H](O/2)CO)O)O)NC(C)=O
Molecular Formula
C15H19N3O7
Molecular Weight
353.33
Precautions
H315, H319, H335
References & Citations
[1]Perreira M, et al. Inhibition of O-GlcNAcase by PUGNAc is dependent upon the oxime stereochemistry. Bioorg Med Chem. 2006;14 (3) :837-846.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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