Flutonidine
Product Specifications
UNSPSC Description
Flutonidine (ST-600) is a Clonidine (HY-12721) analogue that shows antihypertensive and sympatholytic effects. The initial hypertension produced by Flutonidine is due to stimulation of the peripheral α1, α2 adrenoceptors and the subsequent fall in blood pressure is due to the stimulation of central α2 adrenoceptors. Flutonidine reduces the arrhythmogenic and lethal effects of ouabain. Flutonidine is promising for research of ventricular arrhythmias caused by cardiac glycosides[1][2].
Target Antigen
Adrenergic Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein;Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/flutonidine.html
Smiles
FC1=CC=C(C)C(NC2=NCCN2)=C1
Molecular Weight
193.22
References & Citations
[1]Thomas GP, et al. Effect of flutonidine on ouabain-induced arrhythmias and lethality in guinea-pig. Pharmacol Res. 1993 May-Jun;27(4):365-71.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-121312/Flutonidine-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-121312/
Clinical Information
No Development Reported
CAS Number
28125-87-3
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