Flutonidine
Flutonidine (ST-600) is a Clonidine (HY-12721) analogue that shows antihypertensive and sympatholytic effects. The initial hypertension produced by Flutonidine is due to stimulation of the peripheral α1, α2 adrenoceptors and the subsequent fall in blood pressure is due to the stimulation of central α2 adrenoceptors. Flutonidine reduces the arrhythmogenic and lethal effects of ouabain. Flutonidine is promising for research of ventricular arrhythmias caused by cardiac glycosides[1][2].
Product Specifications
CAS Number
[28125-87-3]
Product Name Alternative
ST-600
UNSPSC
12352005
Target
Adrenergic Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/flutonidine.html
Smiles
FC1=CC=C(C)C(NC2=NCCN2)=C1
Molecular Formula
C10H12FN3
Molecular Weight
193.22
References & Citations
[1]Thomas GP, et al. Effect of flutonidine on ouabain-induced arrhythmias and lethality in guinea-pig. Pharmacol Res. 1993 May-Jun;27 (4) :365-71.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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