Sinomenine N-oxide

Sinomenine N-oxide has anti-angiogenic, anti-inflammatory and anti-rheumatic effects. Sinomenine N-oxide is also a NO production inhibitor, with an IC50 value of 23.04 μM[1][2][3].

Product Specifications

CAS Number

[1000026-77-6]

Product Name Alternative

(+) -Sinomenine N-oxide

UNSPSC

12352005

Target

NO Synthase

Type

Natural Products

Related Pathways

Immunology/Inflammation

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/sinomenine-n-oxide.html

Purity

99.0

Solubility

DMSO : ≥ 100 mg/mL

Smiles

OC1=C2[C@]34[C@@](C=C(C(C4)=O)OC)([H])[C@@H]([N@@+]([O-])(CC3)C)CC2=CC=C1OC

Molecular Formula

C19H23NO5

Molecular Weight

345.39

References & Citations

[1]Liu WJ, et al. Network pharmacology approach to elucidate possible action mechanisms of Sinomenii Caulis for treating osteoporosis. J Ethnopharmacol. 2020 Jul 15;257:112871. |[2]Zeng HL, et al. New N-oxide alkaloids from the stems of Sinomenium acutum. Fitoterapia. 2023 Mar;165:105404. |[3]Li Q, et al. Metabolic mechanism and anti-inflammation effects of sinomenine and its major metabolites N-demethylsinomenine and sinomenine-N-oxide. Life Sci. 2020 Nov 15;261:118433.