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Benzocaine-d4

Benzocaine-d4 is the deuterium labeled Benzocaine. Benzocaine shares a common receptor with all othe rLAs in the voltage-gated Na+ channel, with an IC50 of 0.8 mM tested with a potential of +30 mV.

Product Specifications

CAS Number

[342611-08-9]

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

Isotope-Labeled Compounds; Sodium Channel

Type

Isotope-Labeled Compounds

Related Pathways

Membrane Transporter/Ion Channel; Others

Field of Research

Neurological Disease

Purity

99.00

Solubility

DMSO : 100 mg/mL (ultrasonic; warming)

Smiles

CCOC(C1=C([2H])C([2H])=C(C([2H])=C1[2H])N)=O

Molecular Formula

C9H7D4NO2

Molecular Weight

169.21

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Wang GK et al. A common local anesthetic receptor for benzocaine and etidocaine in voltage-gated mu1 Na+ channels. Pflugers Arch. 1998 Jan;435 (2) :293-302.|[3]Di Croce D et al. Drug action of benzocaine on the sarcoplasmic reticulum Ca-ATPase from fast-twitch skeletal muscle. Naunyn Schmiedebergs Arch Pharmacol. 2015 Nov;388 (11) :1163-70.|[4]Davis JA, et al. Benzocaine-induced methemoglobinemia attributed to topical application of the anesthetic in several laboratory animal species. Am J Vet Res. 1993 Aug;54 (8) :1322-6.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, protect from light)

Scientific Category

Isotope-Labeled Compounds

Clinical Information

No Development Reported

Available Sizes

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