Benzocaine-d4
Product Specifications
UNSPSC Description
Benzocaine-d4 is the deuterium labeled Benzocaine. Benzocaine shares a common receptor with all othe rLAs in the voltage-gated Na+ channel, with an IC50 of 0.8 mM tested with a potential of +30 mV.
Target Antigen
Isotope-Labeled Compounds; Sodium Channel
Type
Isotope-Labeled Compounds
Related Pathways
Membrane Transporter/Ion Channel;Others
Field of Research
Neurological Disease
Purity
99.00
Solubility
DMSO : 100 mg/mL (ultrasonic;warming)
Smiles
CCOC(C1=C([2H])C([2H])=C(C([2H])=C1[2H])N)=O
Molecular Weight
169.21
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. |[2]Wang GK et al. A common local anesthetic receptor for benzocaine and etidocaine in voltage-gated mu1 Na+ channels. Pflugers Arch. 1998 Jan;435(2):293-302.|[3]Di Croce D et al. Drug action of benzocaine on the sarcoplasmic reticulum Ca-ATPase from fast-twitch skeletal muscle. Naunyn Schmiedebergs Arch Pharmacol. 2015 Nov;388(11):1163-70.|[4]Davis JA, et al. Benzocaine-induced methemoglobinemia attributed to topical application of the anesthetic in several laboratory animal species. Am J Vet Res. 1993 Aug;54(8):1322-6.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Clinical Information
No Development Reported
CAS Number
342611-08-9
Available Sizes
Curated Selection
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