HPPE

HPPE (compound 236) is an orally active, potential Bach1 inhibitor. Bach1 is a transcription factor of the cap'n'collar type alkaline region leucine zipper factor family (CNC-bZip) that regulates mitochondrial metabolism and reduces glucose utilization. HPPE can be used for research in psoriasis, multiple sclerosis, and COPD[1][2][3][4].

Product Specifications

CAS Number

[1325721-55-8]

Product Name Alternative

Bach1-IN-1

UNSPSC

12352005

Target

Mitochondrial Metabolism

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/hppe.html

Purity

99.46

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

O=C(C1=CC(N=C(N2C)NC3=NC4=C(S3)C=C(C(F)(F)F)C=C4)=C2C=C1)NCCOCCO

Molecular Formula

C21H20F3N5O3S

Molecular Weight

479.48

References & Citations

[1]Attucks, et al. Bach 1 inhibitors in combination with Nrf2 activators and pharmaceutical compositions thereof. World Intellectual Property Organization, WO2016089648 A1 2016-06-09.|[2]Zhang X, et al. Bach1: Function, Regulation, and Involvement in Disease. Oxid Med Cell Longev. 2018 Oct 2;2018:1347969.|[3]Ahuja M, et al. Bach1 derepression is neuroprotective in a mouse model of Parkinson's disease. Proc Natl Acad Sci U S A. 2021 Nov 9;118 (45) :e2111643118. |[4]Freeman R, et al. HPPE Activates NRF2 Signaling by Liberating Heavy Metal Stores. Chembiochem. 2024 Sep 6:e202400529.