AFM32a (hydrochloride)

AFM32a (PAD2-IN-1) hydrochloride, a benzimidazole-based derivative, is a potent and selective protein arginine deiminase 2 (PAD2) inhibitor. AFM32a hydrochloride shows superior selectivity for PAD2 over PAD4 (95-fold) and PAD3 (79-fold) [1].

Product Specifications

CAS Number

[2988594-85-8]

Product Name Alternative

PAD2-IN-1 (hydrochloride)

UNSPSC

12352005

Target

Protein Arginine Deiminase

Type

Reference compound

Related Pathways

Epigenetics

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/afm32a-hydrochloride.html

Purity

99.71

Solubility

DMSO : ≥ 100 mg/mL

Smiles

O=C(C1=CC=CC(CN2)=C1C2=O)N[C@H](C3=NC4=C(OCC)C=CC=C4N3C)CCCNC(CF)=N.[H]Cl

Molecular Formula

C25H30ClFN6O3

Molecular Weight

517.00

References & Citations

[1]Aaron Muth, et al. Development of a Selective Inhibitor of Protein Arginine Deiminase 2. J Med Chem. 2017 Apr 13;60 (7) :3198-3211.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture and light)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Curated Selection

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