AFM32a (hydrochloride)
AFM32a (PAD2-IN-1) hydrochloride, a benzimidazole-based derivative, is a potent and selective protein arginine deiminase 2 (PAD2) inhibitor. AFM32a hydrochloride shows superior selectivity for PAD2 over PAD4 (95-fold) and PAD3 (79-fold) [1].
Product Specifications
CAS Number
[2988594-85-8]
Product Name Alternative
PAD2-IN-1 (hydrochloride)
UNSPSC
12352005
Target
Protein Arginine Deiminase
Type
Reference compound
Related Pathways
Epigenetics
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/afm32a-hydrochloride.html
Purity
99.71
Solubility
DMSO : ≥ 100 mg/mL
Smiles
O=C(C1=CC=CC(CN2)=C1C2=O)N[C@H](C3=NC4=C(OCC)C=CC=C4N3C)CCCNC(CF)=N.[H]Cl
Molecular Formula
C25H30ClFN6O3
Molecular Weight
517.00
References & Citations
[1]Aaron Muth, et al. Development of a Selective Inhibitor of Protein Arginine Deiminase 2. J Med Chem. 2017 Apr 13;60 (7) :3198-3211.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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