What is the catalog number for EHNA?

The catalog number for EHNA is HY-103160B.

What sizes are available for EHNA?

EHNA is available in the following size(s): 1 Each.

EHNA is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures EHNA?

EHNA is manufactured by QuantiMol.

What is the estimated delivery time for EHNA?

Estimated delivery time for EHNA is approximately 15 business day(s), depending on your location.

Where can I find the safety data sheet (SDS/MSDS) for EHNA?

The safety data sheet for EHNA is available here: http://file.medchemexpress.com/batch_PDF/HY-103160B/.

EHNA

EHNA is a potent and selective dual inhibitor of cyclic nucleotide phosphodiesterase 2 (PDE2) (IC50=4 μM) and adenosine deaminase (ADA) . EHNA exerts a concentration inhibition of the cGMP-stimulated PDE II (cGs-PDE) (IC50:0.8 μM (human), 2 μM (porcine myocardium) ), but has smaller inhibitory effect on the unstimulated PDE2 activity. EHNA play roles in mediating diverse pharmacological responses, including antiviral, antitumour and antiarrhythmic effects[1][2][3].

Product Specifications

CAS Number

51350-19-7

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

Adenosine Deaminase; Influenza Virus; Phosphodiesterase (PDE)

Type

Reference compound

Related Pathways

Anti-infection; Metabolic Enzyme/Protease

Applications

COVID-19-anti-virus

Field of Research

Cancer; Infection; Neurological Disease; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/ehna.html

Smiles

CCCCCC[C@@](N1C2=C(C(N)=NC=N2)N=C1)([H])[C@H](O)C

Molecular Formula

C14H23N5O

Molecular Weight

277.37

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Podzuweit T, et al. Isozyme selective inhibition of cGMP-stimulated cyclic nucleotide phosphodiesterases by erythro-9- (2-hydroxy-3-nonyl) adenine.Cell Signal. 1995 Sep;7 (7) :733-8.|[2]Michie AM, et al. Rapid regulation of PDE-2 and PDE-4 cyclic AMP phosphodiesterase activity following ligation of the T cell antigen receptor on thymocytes: analysis using the selective inhibitors erythro-9- (2-hydroxy-3-nonyl) -adenine (EHNA) and rolipram.Cell Signal. 1996 Feb;8 (2) :97-110.|[3]Blázquez-Bermejo C, et al. Increased dNTP pools rescue mtDNA depletion in human POLG-deficient fibroblasts. FASEB J. 2019 Jun;33 (6) :7168-7179.