Asiatic acid

Asiatic acid, a pentacyclic triterpene found in Centella asiatica (Centella asiatica), has anticancer activity. Asiatic acid induces apoptosis in melanoma cells and has barrier protective effects on human aortic endothelial cells (HAEC). Asiatic acid also has anti-inflammatory activity and inhibits tumor necrosis factor (TNF)-α-induced endothelial barrier dysfunction. Asiatic acid also inhibits NLRP3 inflammasome activation and NF-κB pathway, effectively inhibits inflammation in rats, and has neuroprotective effects in rat spinal cord injury (SCI) model[1][2][3][4][5].

[1]Park BC, et al. Asiatic acid induces apoptosis in SK-MEL-2 human melanoma cells. Cancer Lett. 2005 Jan 31;218(1):81-90.|[2]Huang SS, et al. Antinociceptive activities and the mechanisms of anti-inflammation of asiatic Acid in mice. Evid Based Complement Alternat Med. 2011;2011:895857.|[3]Fong LY, et al. Asiatic acid stabilizes cytoskeletal proteins and prevents TNF-α-induced disorganization of cell-cell junctions in human aortic endothelial cells. Vascul Pharmacol. 2019 Jun;117:15-26.|[4]Jiang W, et al. Neuroprotective effect of asiatic acid against spinal cord injury in rats. Life Sci. 2016 Jul 15;157:45-51.|[5]Kong D, et al. Protective effects of Asiatic acid against pelvic inflammatory disease in rats. Exp Ther Med. 2019 Jun;17(6):4687-4692.