UC-112
UC-112 is a new and highly effective inhibitor of apoptosis inhibitory protein IAP, with an IC50 value of 0.7-3.4uM in cancer cells.
Product Specifications
CAS Number
[383392-66-3]
UNSPSC
12352005
Target
Apoptosis; IAP
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/UC-112.html
Concentration
10mM
Purity
98.92
Solubility
DMSO : 33.33 mg/mL (ultrasonic)
Smiles
OC1=C2N=CC=CC2=C(COCC3=CC=CC=C3)C=C1CN4CCCC4
Molecular Formula
C22H24N2O2
Molecular Weight
348.44
References & Citations
[1]Wang J, et al. Discovery of novel second mitochondria-derived activator of caspase mimetics as selective inhibitor of apoptosis protein inhibitors. J Pharmacol Exp Ther. 2014 May;349 (2) :319-29.|[2]Qinghui Wang, et al. Synthesis and biological evaluation of indole-based UC-112 analogs as potent and selective survivin inhibitors. Eur J Med Chem
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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