Glycyl-L-histidyl-L-lysine

Glycyl-L-histidyl-L-lysine is a tripeptide consisting of glycine, L-histidine and L-lysine residues joined in sequence. Glycyl-L-histidyl-L-lysine is a hepatotropic immunosuppressor and shows anxiolytic effect. Glycyl-L-histidyl-L-lysine and its copper complexes show good skin tolerance[1][2][3].

Product Specifications

CAS Number

[49557-75-7]

Product Name Alternative

GHK; Tripeptide-1

UNSPSC

12352209

Hazard Statement

H302, H315, H319, H335

Target

Others

Type

Peptides

Related Pathways

Others

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/glycyl-l-histidyl-l-lysine.html

Purity

99.89

Solubility

H2O : 100 mg/mL (ultrasonic)

Smiles

NCCCC[C@@H](C(O)=O)NC([C@H](CC1=CNC=N1)NC(CN)=O)=O

Molecular Formula

C14H24N6O4

Molecular Weight

340.38

Precautions

H302, H315, H319, H335

References & Citations

[1]Arkadiusz Gruchlik, et al. Effect of Gly-Gly-His, Gly-His-Lys and their copper complexes on TNF-alpha-dependent IL-6 secretion in normal human dermal fibroblasts. Acta Pol Pharm. 2012 Nov-Dec;69 (6) :1303-6.|[2]M Yu Smakhtin, et al. Tripeptide Gly-His-Lys is a hepatotropic immunosuppressor. Bull Exp Biol Med. 2002 Jun;133 (6) :586-7.|[3]I Bobyntsev, et al. Anxiolytic effects of Gly-His-Lys peptide and its analogs. Bull Exp Biol Med. 2015 Apr;158 (6) :726-8.