Kv7.2/Kv7.3 agonist 1
Kv7.2/Kv7.3 agonist 1 (Compound 16) is an orally active agonist for KV7.2/7.3 channel (KCNQ2/3) with an EC50 of 1.03 μM. Kv7.2/Kv7.3 agonist 1 exhibits analgesic efficacy in mice chronic constriction injury (CCI) model and mice Streptozotocin (HY-13753) -induced diabetic peripheral neuropathic pain (DPNP) model, with ED50 of 12.02 and 9.63 mg/kg[1].
Product Specifications
CAS Number
[2315450-35-0]
UNSPSC
12352005
Target
Potassium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/kv7-2-kv7-3-agonist-1.html
Smiles
CC(NC1=NC(OCC2=CC=C(F)C=C2)=CC=C1N)=O
Molecular Formula
C14H14FN3O2
Molecular Weight
275.28
References & Citations
[1]Qian K, et al., Discovery of a novel KV7.2/7.3 channels agonist for the treatment of neuropathic pain. Eur J Med Chem. 2024 Oct 12;280:116953.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Voltage-gated potassium channel
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