Neoruscogenin

Neoruscogenin, a member of the steroidal sapogenin family, is a high-affinity agonist of the nuclear receptor RORα (NR1F1) (EC50 = 0.11 µM) [1].

Product Specifications

CAS Number

[17676-33-4]

UNSPSC

12352005

Hazard Statement

H302

Target

ROR

Type

Natural Products

Related Pathways

Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

Applications

COVID-19-immunoregulation

Field of Research

Infection; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/neoruscogenin.html

Purity

99.24

Solubility

DMSO : 50 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

C[C@@]12[C@]([C@@H]3C)([H])[C@](O[C@]3(OC4)CCC4=C)([H])C[C@@]1([H])[C@@](CC=C(C[C@@H](O)C5)[C@@]6([C@@H]5O)C)([H])[C@]6([H])CC2

Molecular Formula

C27H40O4

Molecular Weight

428.60

Precautions

H302

References & Citations

[1]Helleboid S, et al. The identification of naturally occurring neoruscogenin as a bioavailable, potent, and high-affinity agonist of the nuclear receptor RORα (NR1F1) .J Biomol Screen. 2014 Mar;19 (3) :399-406.|[2]Zhang D, et al. Novel Pro-myogenic Factor Neoruscogenin Induces Muscle Fiber Hypertrophy by Inhibiting MSTN Maturation and Activating the Akt/mTOR Pathway. J Agric Food Chem. 2023 Jan 11;71 (1) :499-511.