OGR1/GPR68
Product Specifications
Background
OGR1 (originally identified as GPR68) is a high-affinity receptor for sphingosylphosphorylcholine (SPC). SPC is a member of a class of bioactive lipids which regulate cellular functions. These functions include cell proliferation and growth inhibition, smooth muscle contration and wound healing. SPC also stimulated signalling pathways that induce tyrosine phosphorylation, activate MAP kinases and protein kinase C, modify ion channel activity and increase intracellular Ca2+ concentration. OGR1 is expressed in placenta, lung, liver, spleen, testis, small intestine and peripheral blood leukocytes. It is not found in thymus, ovary, colon, skeletal muscle, kidney or pancreas.
Species Reactivity
Human
Conjugation
Unconjugated
Type
Control Lysate
Applications
WB
Field of Research
Signal Transduction
Assay Principle
For use as a positive control with Exalpha's OGR1 polyclonal antibody (Cat. No. X1600P) for Western blot analysis.
Stability
See expiration date on vial
Concentration
See vial for Concentration
Form
Provided in 10% glycerol, 0,063 M Tris-HCl (pH 6.8), 2% SDS and 0,002% bromophenol blue, 5% 2-mercaptoethanol
Precautions
This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving Humans or animals.
References & Citations
1. Xu, Y., et al. 'Sphingosylphosphorylcholine is a ligand for ovarian cancer G-protein-coupled receptor 1.' Nature Cell Biol. 2000: 2, 261-267
Shipping Conditions
Ambient Temperature, freeze upon arrival
Storage Conditions
Product should be stored at -20ºC; Aliquot to avoid freeze/thaw cycles
Functional Analysis
WB
Curated Selection
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