OGR1/GPR68

Product Specifications

Background

OGR1 (originally identified as GPR68) is a high-affinity receptor for sphingosylphosphorylcholine (SPC). SPC is a member of a class of bioactive lipids which regulate cellular functions. These functions include cell proliferation and growth inhibition, smooth muscle contration and wound healing. SPC also stimulated signalling pathways that induce tyrosine phosphorylation, activate MAP kinases and protein kinase C, modify ion channel activity and increase intracellular Ca2+ concentration. OGR1 is expressed in placenta, lung, liver, spleen, testis, small intestine and peripheral blood leukocytes. It is not found in thymus, ovary, colon, skeletal muscle, kidney or pancreas.

Species Reactivity

Human

Conjugation

Unconjugated

Type

Control Lysate

Applications

Field of Research

Signal Transduction

Assay Principle

For use as a positive control with Exalpha's OGR1 polyclonal antibody (Cat. No. X1600P) for Western blot analysis.

Stability

See expiration date on vial

Concentration

See vial for Concentration

Form

Provided in 10% glycerol, 0,063 M Tris-HCl (pH 6.8), 2% SDS and 0,002% bromophenol blue, 5% 2-mercaptoethanol

Precautions

This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving Humans or animals.