Anti-p53R2 (NT) Antibody

Rabbit Polyclonal Antibody specific to p53R2 (NT)

Product Specifications

CAS Number

9007-83-4

Product Name Alternative

EC 1.17.4.1, TP53-inducible ribonucleotide reductase M2 B, p53-inducible ribonucleotide reductase small subunit 2-like protein, p53R2

Gene Name

RRM2B

NCBI Gene ID

UniProt

Q7LG56

Cellular Locus

Cytoplasm. Nucleus. Note=Translocates from cytoplasm to nucleus in response to DNA damage.

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

Peptide corresponding to aa 2-17 of human p53R2.

Target Antigen

Ribonucleoside-diphosphate reductase subunit M2 B

Target

p53R2 (NT)

Clonality

Polyclonal

Type

Antibody

Applications

ELISA, WB, IHC-P, IF

Field of Research

Cancer research

Purification Method

Purified by peptide immuno-affinity chromatography

Concentration

1.0 mg/mL

Dilution

Dilute in PBS or medium which is identical to that used in the assay system.

Format

Purified

Form

Liquid

Buffer

Phosphate Buffered Saline

Function

Plays a pivotal role in cell survival by repairing damaged DNA in a p53/TP53-dependent manner. Supplies deoxyribonucleotides for DNA repair in cells arrested at G1 or G2. Contains an iron-tyrosyl free radical center required for catalysis. Forms an active ribonucleotide reductase (RNR) complex with RRM1 which is expressed both in resting and proliferating cells in response to DNA damage. {PubMed:10716435, PubMed:11517226, PubMed:11719458}.