Anti-Eotaxin Antibody

Rabbit Polyclonal Antibody specific to Eotaxin (CT)

Product Specifications

CAS Number

9007-83-4

Product Name Alternative

C-C motif chemokine 11, Eosinophil chemotactic protein, Small-inducible cytokine A11

Gene Name

CCL11

Gene ID

6356

NCBI Gene ID

UniProt

P51671

Accession Number

NP_002977.1

Cellular Locus

Secreted

Host

Rabbit

Reactivity

Human

Immunogen

Peptide corresponding to aa 83-97 of human eotaxin.

Target Antigen

Eotaxin

Target

Eotaxin

Clonality

Polyclonal

Isotype

IgG

Type

Antibody

Applications

ELISA, WB, ICC, IF

Field of Research

Infectious Disease

Purification Method

Purified by peptide immuno-affinity chromatography

Concentration

Lot Specific

Dilution

Dilute in PBS or medium which is identical to that used in the assay system.

Format

Purified

Form

Liquid

Buffer

Phosphate Buffered Saline

Function

In response to the presence of allergens, this protein directly promotes the accumulation of eosinophils, a prominent feature of allergic inflammatory reactions (PubMed:8597956). Binds to CCR3 (PubMed:8631813). {PubMed:8597956, PubMed:8631813}.

Additionnal Information

Immunoblotting: use at 1:500-1:1,000 dilution. <br><br>Positive control: Native and recombi- nant protein.

Storage Conditions

This antibody is stable for at least one (1) year at -20°C. Avoid multiple freeze- thaw cycles.

Specificity

This antibody recognizes the monomeric (9 kD) and dimeric (18 kD) forms of human eotaxin

Formulation

PBS, pH 7.4.

Buffer pH

pH 7.4

Target Background

Chemokines play a key role in inflammation. The CC chemokine eotaxin is a potent and specific eosinophil chemoattractant that is expressed by a variety of cell types in certain inflammatory conditions. Some G-protein coupled chemokine receptors are also utilized as virus coreceptors for fusion and infection of cells. The eotaxin receptor CCR3 is required for HIV-1 entry into target cells such as microglia, and eotaxin inhibits infection by HIV-1.