HNMPA- (AM) 3
HNMPA- (AM) 3 is a cell-permeable and selective insulin receptor tyrosine kinase inhibitor analog of HNMPA. HNMPA- (AM) 3 greatly inhibits the ability of prothoracicotropic hormone (PTTH) to activate ERK phosphorylation and stimulate ecdysteroidogenesis. HNMPA- (AM) 3 is also effective in inhibiting ecdysteroid production (IC50=14.2 μM) and insulin receptor activity (IC50 is 14.2 μM and 200 μM in mosquitoes and mammals, respectively) [1][2].
Product Specifications
CAS Number
[120944-03-8]
UNSPSC
12352005
Hazard Statement
H225, H319
Target
Insulin Receptor
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/hnmpa-am-3.html
Purity
98.04
Solubility
DMSO : ≥ 100 mg/mL
Smiles
CC(OCOC(C1=CC2=CC=CC=C2C=C1)P(OCOC(C)=O)(OCOC(C)=O)=O)=O
Molecular Formula
C20H23O10P
Molecular Weight
454.36
Precautions
H225, H319
References & Citations
2+
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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