HNMPA-(AM)3
Product Specifications
UNSPSC Description
HNMPA-(AM)3 is a cell-permeable and selective insulin receptor tyrosine kinase inhibitor analog of HNMPA. HNMPA-(AM)3 greatly inhibits the ability of prothoracicotropic hormone (PTTH) to activate ERK phosphorylation and stimulate ecdysteroidogenesis. HNMPA-(AM)3 is also effective in inhibiting ecdysteroid production (IC50=14.2 μM) and insulin receptor activity (IC50 is 14.2 μM and 200 μM in mosquitoes and mammals, respectively)[1][2].
Target Antigen
Insulin Receptor
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/hnmpa-am-3.html
Purity
97.22
Solubility
DMSO : ≥ 100 mg/mL
Smiles
CC(OCOC(C1=CC2=CC=CC=C2C=C1)P(OCOC(C)=O)(OCOC(C)=O)=O)=O
Molecular Weight
454.36
References & Citations
[1]Gu SH, et al. PTTH-stimulated ERK phosphorylation in prothoracic glands of the silkworm, Bombyx mori: role of Ca<sup>2+</sup>/calmodulin and receptor tyrosine kinase. J Insect Physiol. 2010;56(1):93-101. |[2]Riehle MA, et al. Insulin stimulates ecdysteroid production through a conserved signaling cascade in the mosquito Aedes aegypti. Insect Biochem Mol Biol. 1999 Oct;29(10):855-60.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-124097/HNMPA-AM-3-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-124097/HNMPA-AM-3-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
120944-03-8
Available Sizes
Curated Selection
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