bio-THZ1
Product Specifications
UNSPSC Description
bio-THZ1 is a biotinylated version of THZ1 and binds irreversibly to CDK7. THZ1 is a selective and potent covalent CDK7 inhibitor with an IC50 of 3.2 nM[1].
Target Antigen
CDK
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/bio-thz1.html
Purity
98.06
Solubility
DMSO : 120 mg/mL (ultrasonic)
Smiles
O=C(NCCOCCOCCOCCNC(NCCCN(C)C/C=C/C(NC1=CC=C(C(NC2=CC=CC(NC3=NC=C(Cl)C(C4=CNC5=C4C=CC=C5)=N3)=C2)=O)C=C1)=O)=O)CCCC[C@@H]6SC[C@]([C@]6([H])N7)([H])NC7=O
Molecular Weight
1053.67
References & Citations
[1]Kwiatkowski N, et al. Targeting transcription regulation in cancer with a covalent CDK7 inhibitor. Nature. 2014 Jul 31;511(7511):616-20.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-128867/bio-THZ1-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-128867/bio-THZ1-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
1604811-14-4
Available Sizes
Curated Selection
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