PROTAC c-Met degrader-2
PROTAC c-Met degrader-2 (PROTAC2) is a PROTAC-based c-Met degrader, with a DC50 of 50 nM (Pink: Foretinib ; Black: linker (HY-45124) ; Blue: CRBN ligand Thalidomide-4-O-C2-NH2 (HY-136162A) )[2].
Product Specifications
CAS Number
2254608-80-3
UNSPSC
12352005
Target
C-Met/HGFR; PROTACs
Type
Reference compound
Related Pathways
PROTAC; Protein Tyrosine Kinase/RTK
Applications
Cancer-programmed cell death
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/protac-c-met-degrader-2.html
Smiles
O=C1NC(C(CC1)N2C(C3=C(C2=O)C(OCCNC(CCOCCCOCCCOC4=CC5=NC=CC(OC6=CC=C(NC(C7(CC7)C(NC8=CC=C(C=C8)F)=O)=O)C=C6F)=C5C=C4OC)=O)=CC=C3)=O)=O
Molecular Formula
C51H50F2N6O13
Molecular Weight
992.97
References & Citations
[1]Nan Bai, et al. Rationalizing PROTAC-Mediated Ternary Complex Formation Using Rosetta. J Chem Inf Model|[2]Andrew P. Crew, et al. Modulators of proteolysis and associated methods of use. WO2018226542A1.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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