Cynomolgus Complement C2 Protein, His Tag (active enzyme)
Cynomolgus Complement C2, His Tag (CO2-C52H8) is expressed from human 293 cells (HEK293) . It contains AA Ala 21 - Leu 752 (Accession # G8F3W0-1) .
Product Specifications
Background
C2 is a major histocompatibility complex class-III protein. Component C2 which is part of the classical pathway of the complement system is cleaved by activated factor C1 into two fragments: C2b and C2a. C2a, a serine protease, then combines with complement factor C4b to generate the C3 or C5 convertase. The lectin (LP) and classical (CP) pathways are two of the three main activation cascades of the complement system. These pathways start with recognition of different pathogen- or danger-associated molecular patterns and include identical steps of proteolytic activation of complement component C4, formation of the C3 proconvertase C4b2, followed by cleavage of complement component C2 within C4b2 resulting in the C3 convertase C4b2a.
Specifications
This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 83.0 kDa. The protein migrates as 90-100 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Accession Number
G8F3W0-1
Expression Region
Ala 21 - Leu 752
Host
HEK293
Target
Complement C2
Conjugation
Unconjugated
Tag
C-10xHis
Source
Cynomolgus
Stability
● -20°C to -70°C for 12 months in lyophilized state; ● -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Endotoxin
1.0 EU per μg
Purity
95%
Format
Powder
Buffer
20 mM Tris, 150 mM NaCl, pH7.5
Additives
Trehalose
Molecular Weight
83.0 kDa
Shipping Conditions
RT
Storage Conditions
-20°C
Package Size
500ug*2
Product Datasheet
Https://www.acrobiosystems.com/static/main/products/pdf/ds/CO2-C52H8.pdf
Species
Cynomolgus
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