MTOR inhibitor-10
MTOR inhibitor-10 (Compound 9c) is a selective inhibitor for mTOR. mTOR inhibitor-10 inhibits mTOR and PI3K-α, with IC50 of 0.7 and 825 nM. mTOR inhibitor-10 inhibits proliferation of LNCaP with IC50 of 87 nM[1].
Product Specifications
CAS Number
1144075-36-4
UNSPSC
12352005
Target
MTOR; PI3K
Type
Reference compound
Related Pathways
PI3K/Akt/mTOR
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/mtor-inhibitor-10.html
Solubility
10 mM in DMSO
Smiles
O=C(NCCF)NC1=CC=C(C2=NC3=C(C(N4CC5OC(CC5)C4)=N2)SC=C3)C=C1
Molecular Formula
C21H22FN5O2S
Molecular Weight
427.50
References & Citations
[1]Verheijen JC, et al., Discovery of 2-arylthieno[3,2-d]pyrimidines containing 8-oxa-3-azabi-cyclo[3.2.1]octane in the 4-position as potent inhibitors of mTOR with selectivity over PI3K. Bioorg Med Chem Lett. 2010 Jan 1;20 (1) :375-9.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
MTOR; PI3Kα
Available Sizes
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