MMRi64
MMRi64 disrupts Mdm2-MdmX interactions. MMRi64 downregulates Mdm2 and MdmX in leukemia cells. MMRi64 induces p53 accumulation, and induces the apoptotic arm of the p53 pathway in leukemia/lymphoma cells. MMRi64 can be used for cancer research[1].
Product Specifications
CAS Number
430458-66-5
UNSPSC
12352005
Target
Apoptosis; MDM-2/p53
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/mmri64.html
Purity
98.0
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
OC1=C2N=CC=CC2=CC=C1C(C3=CC=CC(Cl)=C3Cl)NC4=NC=CC(C)=C4
Molecular Formula
C22H17Cl2N3O
Molecular Weight
410.30
References & Citations
[1]Wu W, et al. Targeting RING domains of Mdm2-MdmX E3 complex activates apoptotic arm of the p53 pathway in leukemia/lymphoma cells. Cell Death Dis. 2015 Dec 31;6 (12) :e2035.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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