Cycloguanil-d4 (hydrochloride)
Cycloguanil-d4 (hydrochloride) is the deuterium labeled Cycloguanil hydrochloride. Cycloguanil hydrochloride, the active metabolite of Proguanil, acts on malaria schizonts in erythrocytes and hepatocytes[1].
Product Specifications
CAS Number
1189427-23-3
UNSPSC
12352005
Target
Drug Metabolite; Isotope-Labeled Compounds; Parasite
Type
Isotope-Labeled Compounds
Related Pathways
Anti-infection; Metabolic Enzyme/Protease; Others
Field of Research
Infection
Solubility
10 mM in DMSO
Smiles
CC1(N(C2=C([2H])C([2H])=C(C([2H])=C2[2H])Cl)C(N)=NC(N)=N1)C.Cl
Molecular Formula
C11H11D4Cl2N5
Molecular Weight
292.20
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Matthaei J, et al. OCT1 Deficiency Affects Hepatocellular Concentrations and Pharmacokinetics of Cycloguanil, the Active Metabolite of the Antimalarial Drug Proguanil. Clin Pharmacol Ther. 2019 Jan;105 (1) :190-200.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported
Isoform
Plasmodium
Available Sizes
Frequently Asked Questions
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