Glimepiride
Glimepiride (Glimperide) is a medium-to-long acting sulfonylurea anti-diabetic compound with an ED50 of 182 μg/kg.
Product Specifications
CAS Number
93479-97-1
Product Name Alternative
Glimperide; HOE-490
UNSPSC
12352005
Hazard Statement
H301, H319, H331, H361
Target
Amyloid-β
Type
Reference compound
Related Pathways
Neuronal Signaling
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/glimepiride.html
Concentration
10mM
Purity
99.92
Solubility
DMSO : 33.33 mg/mL (ultrasonic) |H2O : < 0.1 mg/mL
Smiles
O=C(N1C(C(CC)=C(C)C1)=O)NCCC2=CC=C(S(=O)(NC(N[C@H]3CC[C@H](C)CC3)=O)=O)C=C2
Molecular Formula
C24H34N4O5S
Molecular Weight
490.62
Precautions
H301, H319, H331, H361
References & Citations
[1]Geisen, K., Special pharmacology of the new sulfonylurea glimepiride. Arzneimittelforschung, 1988. 38 (8) : p. 1120-30.|[2]Liu, F., et al., Glimepiride attenuates Abeta production via suppressing BACE1 activity in cortical neurons. Neurosci Lett, 2013. 557 Pt B: p. 90-4.|[3]Basit, A., M. Riaz, and A. Fawwad, Glimepiride: evidence-based facts, trends, and observations (GIFTS) . [corrected]. Vasc Health Risk Manag, 2012. 8: p. 463-72.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched
Available Sizes
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