Glimepiride

Glimepiride (Glimperide) is a medium-to-long acting sulfonylurea anti-diabetic compound with an ED50 of 182 μg/kg.

Product Specifications

CAS Number

[93479-97-1]

Product Name Alternative

Glimperide; HOE-490

UNSPSC

12352005

Hazard Statement

H301, H319, H331, H361

Target

Amyloid-β

Type

Reference compound

Related Pathways

Neuronal Signaling

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/glimepiride.html

Concentration

10mM

Purity

99.92

Solubility

DMSO : 33.33 mg/mL (ultrasonic) |H2O : < 0.1 mg/mL

Smiles

O=C(N1C(C(CC)=C(C)C1)=O)NCCC2=CC=C(S(=O)(NC(N[C@H]3CC[C@H](C)CC3)=O)=O)C=C2

Molecular Formula

C24H34N4O5S

Molecular Weight

490.62

Precautions

H301, H319, H331, H361

References & Citations

[1]Geisen, K., Special pharmacology of the new sulfonylurea glimepiride. Arzneimittelforschung, 1988. 38 (8) : p. 1120-30.|[2]Liu, F., et al., Glimepiride attenuates Abeta production via suppressing BACE1 activity in cortical neurons. Neurosci Lett, 2013. 557 Pt B: p. 90-4.|[3]Basit, A., M. Riaz, and A. Fawwad, Glimepiride: evidence-based facts, trends, and observations (GIFTS) . [corrected]. Vasc Health Risk Manag, 2012. 8: p. 463-72.